2012 US Open – Men's singles

Andy Murray defeated the defending champion Novak Djokovic in the final, 7–6(12–10), 7–5, 2–6, 3–6, 6–2 to win the men's singles tennis title at the 2012 US Open. It was his first major title, following four previous runner-up finishes. He became the first British man to win a singles major since Fred Perry in 1936, having been runner-up on four previous occasions. The final lasted 4 hours and 54 minutes, an Open Era record-equaling US Open final duration.

This tournament marked the last professional appearance of 2003 champion and former world No. 1 Andy Roddick. He lost to Juan Martín del Potro in the fourth round.

This tournament marked the first time since the 2004 French Open that neither Roger Federer nor Rafael Nadal (who withdrew from the tournament due to a knee injury) reached the semifinals of a major.

Seeds
• Roger Federer (quarterfinals)

• 🇷🇸 Novak Djokovic (final)

• 🇬🇧 Andy Murray (champion)

• 🇪🇸 David Ferrer (semifinals)

• 🇫🇷 Jo-Wilfried Tsonga (second round)

• 🇨🇿 Tomáš Berdych (semifinals)

• 🇦🇷 Juan Martín del Potro (quarterfinals)

• 🇷🇸 Janko Tipsarević (quarterfinals)

• 🇺🇸 John Isner (third round)

• 🇦🇷 Juan Mónaco (first round)

• 🇪🇸 Nicolás Almagro (fourth round)

• Marin Čilić (quarterfinals)

• 🇫🇷 Richard Gasquet (fourth round)

• 🇺🇦 Alexandr Dolgopolov (third round)

• 🇨🇦 Milos Raonic (fourth round)

• 🇫🇷 Gilles Simon (third round)

• 🇯🇵 Kei Nishikori (third round)

•  Stan Wawrinka (fourth round, retired because of illness)

• 🇩🇪 Philipp Kohlschreiber (fourth round)

• 🇺🇸 Andy Roddick (fourth round)

• 🇩🇪 Tommy Haas (first round)

• 🇩🇪 Florian Mayer (first round, retired because of dizziness)

• 🇺🇸 Mardy Fish (fourth round, withdrew for health reasons)

• 🇪🇸 Marcel Granollers (second round)

• 🇪🇸 Fernando Verdasco (third round)

• 🇮🇹 Andreas Seppi (first round)

• 🇺🇸 Sam Querrey (third round)

• 🇷🇺 Mikhail Youzhny (first round)

• 🇷🇸 Viktor Troicki (first round)

• 🇪🇸 Feliciano López (third round)

• 🇫🇷 Julien Benneteau (third round)

• 🇫🇷 Jérémy Chardy (third round)