2012 Winston-Salem Open – Singles

John Isner successfully defended his title by beating Tomáš Berdych 3–6, 6–4, 7–6(11–9) in the final.

Seeds
All seeds received a bye into the second round. • # 🇫🇷 Jo-Wilfried Tsonga (semifinals)

• # 🇨🇿 Tomáš Berdych (final)

• # 🇺🇸 John Isner (champion)

• # 🇺🇦 Alexandr Dolgopolov (quarterfinals)

• # 🇺🇸 Andy Roddick (third round)

• # 🇪🇸 Marcel Granollers (quarterfinals)

• # 🇺🇸 Sam Querrey (semifinals)

• # 🇫🇷 Julien Benneteau (second round)

• # 🇪🇸 Feliciano López (third round)

• # 🇷🇸 Viktor Troicki (second round)

• # 🇺🇿 Denis Istomin (second round)

• # Kevin Anderson (second round)

• # 🇦🇹 Jürgen Melzer (third round)

• # 🇦🇷 David Nalbandian (third round)

• # 🇪🇸 Pablo Andújar (second round)

• # 🇫🇮 Jarkko Nieminen (third round)

Seeds
• # 🇦🇺 Matthew Ebden (second round, retired because of an illness)

• # 🇪🇪 Jürgen Zopp (first round)

• # 🇫🇷 Michaël Llodra (second round)

• # 🇵🇱 Jerzy Janowicz (qualifying competition)

• # 🇩🇪 Benjamin Becker (qualified)

• # 🇩🇪 Cedrik-Marcel Stebe (first round)

• # 🇺🇦 Sergiy Stakhovsky (qualified)

• # 🇫🇷 Guillaume Rufin (second round)

Qualifiers
• # 🇺🇦 Sergiy Stakhovsky

• # 🇺🇸 Michael McClune

• # 🇩🇪 Benjamin Becker

• # Ernests Gulbis