2021 US Open – Girls' doubles

Kamilla Bartone and Oksana Selekhmeteva were the defending champions, having won the previous edition in 2019, however Bartone was no longer eligible to participate in junior events, whilst Selekhmeteva chose not to participate.

Ashlyn Krueger and Robin Montgomery won the title, defeating Reese Brantmeier and Elvina Kalieva in the final, 5–7, 6–3, [10–4].

Seeds
All seeds received a bye into the second round. • # 🇦🇩 Victoria Jiménez Kasintseva / 🇪🇸 Ane Mintegi del Olmo (semifinals)

• # 🇧🇾 Kristina Dmitruk / 🇷🇺 Diana Shnaider (quarterfinals)

• # 🇺🇸 Ashlyn Krueger / 🇺🇸 Robin Montgomery (champions)

• # Petra Marčinko / 🇭🇺 Natália Szabanin (second round)

• # 🇨🇿 Brenda Fruhvirtová / 🇨🇿 Linda Fruhvirtová (quarterfinals)

• # Alex Eala / 🇧🇪 Hanne Vandewinkel (semifinals)

• # 🇩🇪 Mara Guth / 🇩🇪 Julia Middendorf (quarterfinals)

• # 🇺🇸 Reese Brantmeier / 🇺🇸 Elvina Kalieva (final)