2022 Abierto Tampico – Singles

This was the first edition of the tournament as a WTA 125 tournament.

Elisabetta Cocciaretto defeated Magda Linette in the final, 7–6(7–5), 4–6, 6–1 to win the inaugural women's singles tennis title at the 2022 Abierto Tampico Open. This was Cocciaretto's first WTA 125 title.

Seeds
• #🇧🇪 Elise Mertens (quarterfinals)

• #🇨🇿 Marie Bouzková (second round)

• #🇨🇦 Leylah Fernandez (quarterfinals)

• #🇨🇿 Kateřina Siniaková (quarterfinals)

• #🇵🇱 Magda Linette (final)

• #🇨🇳 Zhu Lin (semifinals)

• #🇨🇴 Camila Osorio (quarterfinals)

• #🇨🇦 Rebecca Marino (semifinals)

Seeds
• # 🇺🇸 Sachia Vickery (qualified)

• # 🇺🇸 Elvina Kalieva (qualified)

• # Lulu Sun (qualifying competition, retired)

• # 🇨🇳 You Xiaodi (moved to main draw)

• # Jana Kolodynska (qualifying competition)

• # 🇻🇪 Andrea Gámiz (qualifying competition)

• # Aldila Sutjiadi (qualified)

• # 🇨🇦 Bianca Fernandez (qualified)

Qualifiers
• # 🇺🇸 Sachia Vickery

• # 🇺🇸 Elvina Kalieva

• # Aldila Sutjiadi

• # 🇨🇦 Bianca Fernandez