2022 Karlsruhe Open

The 2022 Karlsruhe Open (also known as the Liqui Moly Open for sponsorship reasons) was a professional tennis tournament played on outdoor clay courts. It was the 3rd edition of the tournament and part of the 2022 WTA 125 tournaments, offering a total of $115,000 in prize money. It took place in Karlsruhe, Germany between 10 and 15 May 2022.

Seeds

 * 1 Rankings as of 25 April 2022.

Other entrants
The following players received a wildcard into the singles main draw:
 * 🇩🇪 Eva Lys
 * 🇩🇪 Ella Seidel
 * 🇩🇪 Laura Siegemund
 * Maria Timofeeva

The following players received entry into the singles main draw through protected ranking:
 * 🇦🇺 Priscilla Hon
 * Bibiane Schoofs

Withdrawals

 * Before the tournament
 * 🇷🇴 Irina Bara → replaced by Bibiane Schoofs
 * 🇬🇧 Harriet Dart → replaced by 🇵🇱 Katarzyna Kawa
 * Vitalia Diatchenko → replaced by 🇱🇮 Kathinka von Deichmann

Seeds

 * 1 Rankings as of 25 April 2022.

Other entrants
The following pair received a wildcard into the doubles main draw:
 * Amina Anshba /  Maria Timofeeva

Singles

 * 🇪🇬 Mayar Sherif def. 🇺🇸 Bernarda Pera 6–2, 6–4

Doubles

 * 🇪🇬 Mayar Sherif / 🇭🇺 Panna Udvardy def. Yana Sizikova / 🇧🇪 Alison Van Uytvanck 5–7, 6–4, [10–2]