2022 L'Open 35 de Saint-Malo – Singles

Viktorija Golubic was the defending champion, but chose not to participate.

Beatriz Haddad Maia won the title, defeating Anna Blinkova in the final, 7–6(7–3), 6–3.

Seeds
• #🇺🇸 Madison Brengle (quarterfinals)

• #🇵🇱 Magda Linette (quarterfinals)

• #🇪🇬 Mayar Sherif (second round)

• #🇧🇷 Beatriz Haddad Maia (champion)

• #🇧🇪 Maryna Zanevska (semifinals, retired)

• # Anna Kalinskaya (first round)

• #🇺🇸 Claire Liu (quarterfinals)

• #🇵🇱 Magdalena Fręch (semifinals)

Seeds
• # 🇧🇷 Laura Pigossi (qualified)

• # 🇫🇷 Jessika Ponchet (moved to main draw)

• # Anastasia Zakharova (first round)

• # 🇦🇺 Jaimee Fourlis (qualified)

• # 🇫🇷 Carole Monnet (qualifying competition)

• # 🇧🇪 Magali Kempen (qualifying competition)

• # 🇹🇭 Peangtarn Plipuech (first round)

• # 🇫🇷 Marine Partaud (qualifying competition)

Qualifiers
• # 🇧🇷 Laura Pigossi

• # 🇯🇵 Eri Hozumi

• # 🇫🇷 Estelle Cascino

• # 🇦🇺 Jaimee Fourlis