2012 Italian Open – Women's singles

Defending champion Maria Sharapova defeated Li Na in the final, 4–6, 6–4, 7–6(7–5) to win the women's singles tennis title at the 2012 Italian Open. She came back from a set and a double break deficit in the second set of the final, and saved a championship point in the third set.

Seeds
The top eight seeds receive a bye into the second round.

🇧🇾 Victoria Azarenka (third round, withdrew because of a shoulder injury) 🇷🇺 Maria Sharapova (champion) 🇵🇱 Agnieszka Radwańska (second round) 🇨🇿 Petra Kvitová (quarterfinals) 🇦🇺 Samantha Stosur (third round) Caroline Wozniacki (second round, retired) 🇫🇷 Marion Bartoli (second round) 🇨🇳 Li Na (final) 🇺🇸 Serena Williams (semifinal, withdrew due to a lower back injury) 🇮🇹 Francesca Schiavone (first round) 🇩🇪 Sabine Lisicki (first round) 🇩🇪 Angelique Kerber (semifinals) 🇷🇸 Ana Ivanovic (third round) 🇸🇰 Dominika Cibulková (quarterfinals) 🇷🇸 Jelena Janković (first round) 🇷🇺 Maria Kirilenko (first round)

Seeds
• # 🇪🇸 Carla Suárez Navarro (first round)

• # Petra Martić (first round)

• # 🇨🇦 Aleksandra Wozniak (qualified)

• # 🇪🇸 Sílvia Soler Espinosa (qualified)

• # 🇺🇦 Kateryna Bondarenko (first round, retired)

• # 🇫🇷 Pauline Parmentier (qualifying competition)

• # Hsieh Su-wei (qualifying competition)

• # Anna Tatishvili (first round)

• # 🇭🇺 Gréta Arn (first round)

• # 🇷🇺 Vera Dushevina (qualifying competition)

• # 🇧🇾 Olga Govortsova (qualified)

• # 🇺🇸 Varvara Lepchenko (qualifying competition)

• # 🇸🇪 Johanna Larsson (first round)

• # 🇺🇸 Sloane Stephens (qualified)

• # 🇫🇷 Mathilde Johansson (first round)

• # 🇺🇸 Jamie Hampton (first round)

Qualifiers
• # Mirjana Lučić

• # 🇨🇿 Andrea Hlaváčková

• # 🇨🇦 Aleksandra Wozniak

• # 🇪🇸 Sílvia Soler Espinosa

• # 🇦🇺 Anastasia Rodionova

• # 🇧🇾 Olga Govortsova

• # 🇺🇸 Sloane Stephens

• # 🇷🇺 Anna Chakvetadze