2012 Sony Ericsson Open – Women's singles

Agnieszka Radwańska defeated Maria Sharapova in the final, 7–5, 6–4 to win the women's singles tennis title at the 2012 Miami Open. It was her second Premier Mandatory title and first Miami Masters title. Radwańska did not drop a set during the tournament.

Victoria Azarenka was the defending champion, but lost to Marion Bartoli in the quarterfinals, ending Azarenka's 26-match winning streak to start the 2012 season.

This tournament also marked the first WTA Tour main draw appearance of two-time major champion and future world No. 1, Garbiñe Muguruza, where she made the fourth round before losing to Radwańska.

Seeds
All seeds received a bye into the second round.

🇧🇾 Victoria Azarenka (quarterfinals) 🇷🇺 Maria Sharapova (final) 🇨🇿 Petra Kvitová (second round) Caroline Wozniacki (semifinals) 🇵🇱 Agnieszka Radwańska (champion) 🇦🇺 Samantha Stosur (fourth round) 🇫🇷 Marion Bartoli (semifinals) 🇨🇳 Li Na (quarterfinals) 🇷🇺 Vera Zvonareva (second round) 🇺🇸 Serena Williams (quarterfinals) 🇮🇹 Francesca Schiavone (second round) 🇩🇪 Sabine Lisicki (fourth round) 🇷🇸 Jelena Janković (second round) 🇩🇪 Julia Görges (second round) 🇷🇸 Ana Ivanovic (fourth round) 🇸🇰 Dominika Cibulková (fourth round) 🇨🇳 Peng Shuai (third round) 🇩🇪 Angelique Kerber (second round) 🇷🇺 Anastasia Pavlyuchenkova (second round) 🇸🇰 Daniela Hantuchová (third round) 🇮🇹 Roberta Vinci (third round) 🇷🇺 Maria Kirilenko (fourth round) 🇧🇪 Yanina Wickmayer (fourth round) 🇮🇹 Flavia Pennetta (third round) 🇪🇸 Anabel Medina Garrigues (second round) 🇷🇺 Svetlana Kuznetsova (second round) 🇨🇿 Lucie Šafářová (second round) Monica Niculescu (second round) 🇨🇿 Petra Cetkovská (third round) 🇮🇹 Sara Errani (second round) 🇪🇪 Kaia Kanepi (second round) 🇷🇺 Nadia Petrova (second round)

Seeds
🇺🇦 Kateryna Bondarenko (qualified) 🇬🇧 Anne Keothavong (first round) Hsieh Su-wei (qualifying competition) 🇷🇺 Vera Dushevina (qualified) 🇺🇸 Varvara Lepchenko (qualifying competition) 🇷🇺 Alexandra Panova (first round) 🇵🇱 Urszula Radwańska (qualified) 🇧🇾 Olga Govortsova (first round) 🇫🇷 Stéphanie Foretz Gacon (qualified) 🇺🇸 Sloane Stephens (qualified) 🇨🇦 Stéphanie Dubois (first round) 🇱🇺 Mandy Minella (qualifying competition) 🇦🇹 Patricia Mayr-Achleitner (first round) 🇷🇴 Edina Gallovits-Hall (first round) 🇷🇺 Nina Bratchikova (first round) Arantxa Rus (qualifying competition) 🇺🇸 Jamie Hampton (qualified) 🇺🇸 Irina Falconi (first round) 🇦🇺 Anastasia Rodionova (qualifying competition) Chang Kai-chen (first round, retired) 🇪🇸 Lara Arruabarrena Vecino (first round) 🇨🇿 Eva Birnerová (qualified) 🇷🇺 Alla Kudryavtseva (first round) 🇷🇺 Valeria Savinykh (qualified)

Qualifiers
🇺🇦 Kateryna Bondarenko 🇯🇵 Misaki Doi 🇫🇷 Alizé Cornet 🇷🇺 Vera Dushevina 🇷🇺 Valeria Savinykh 🇭🇺 Melinda Czink 🇵🇱 Urszula Radwańska 🇺🇸 Madison Keys 🇫🇷 Stéphanie Foretz Gacon 🇺🇸 Sloane Stephens 🇨🇿 Eva Birnerová 🇺🇸 Jamie Hampton