1995 US Open – Mixed doubles

Elna Reinach and Patrick Galbraith were the defending champions but lost in the first round to Mary Pierce and Luke Jensen.

Meredith McGrath and Matt Lucena won in the final 6–4, 6–4 against Gigi Fernández and Cyril Suk.

Seeds
Champion seeds are indicated in bold text while text in italics indicates the round in which those seeds were eliminated.

• # Larisa Neiland / 🇦🇺 Mark Woodforde (first round)

• # 🇺🇸 Lisa Raymond / Mark Knowles (first round)

• # 🇺🇸 Gigi Fernández / 🇨🇿 Cyril Suk (final)

• # Brenda Schultz-McCarthy / 🇺🇸 Rick Leach (quarterfinals)

• # Elna Reinach / 🇺🇸 Patrick Galbraith (first round)

• # 🇺🇸 Martina Navratilova / 🇺🇸 Jonathan Stark (quarterfinals)

• # Manon Bollegraf / 🇺🇸 Trevor Kronemann (first round)

• # 🇺🇸 Mary Joe Fernández / 🇦🇺 Sandon Stolle (withdrew)