1992 US Open – Mixed doubles

Manon Bollegraf and Tom Nijssen were the defending champions but only Nijssen competed that year with Helena Suková.

Suková and Nijssen lost in the final 4–6, 6–3, 6–3 against Nicole Provis and Mark Woodforde.

Seeds
Champion seeds are indicated in bold text while text in italics indicates the round in which those seeds were eliminated.

• # 🇪🇸 Arantxa Sánchez Vicario / 🇦🇺 Todd Woodbridge (second round)

• # 🇺🇸 Gigi Fernández / 🇺🇸 Kelly Jones (first round)

• # Larisa Neiland / Cyril Suk (first round)

• # 🇺🇸 Zina Garrison / 🇺🇸 Rick Leach (quarterfinals)

• # Helena Suková /  Tom Nijssen (final)

• # 🇦🇺 Nicole Provis / 🇦🇺 Mark Woodforde (champions)

• # Elna Reinach / 🇺🇸 Patrick Galbraith (semifinals)

• # 🇦🇺 Rachel McQuillan / 🇦🇺 David Macpherson (second round)