2022 US Open – Mixed doubles

Storm Sanders and John Peers defeated Kirsten Flipkens and Édouard Roger-Vasselin in the final, 4–6, 6–4, [10–7] to win the mixed doubles tennis title at the 2022 US Open.

Desirae Krawczyk and Joe Salisbury were the reigning champions, but Salisbury did not participate this year. Krawczyk partnered Neal Skupski, but lost in the second round to Caty McNally and William Blumberg.

Seeds
• # 🇺🇸 Desirae Krawczyk / 🇬🇧 Neal Skupski (second round)

• # 🇨🇳 Zhang Shuai / Mate Pavić (semifinals)

• # 🇲🇽 Giuliana Olmos / Marcelo Arévalo (first round)

• # 🇦🇺 Storm Sanders / 🇦🇺 John Peers (champions)

• # 🇺🇸 Jessica Pegula / 🇺🇸 Austin Krajicek (second round)

• # 🇨🇳 Yang Zhaoxuan / 🇮🇳 Rohan Bopanna (first round)

• # 🇦🇺 Ellen Perez / 🇳🇿 Michael Venus (second round)

• # Demi Schuurs /  Matwé Middelkoop (first round)

Wild cards
• 🇺🇸 Louisa Chirico / 🇺🇸 Bradley Klahn

• 🇺🇸 Jaeda Daniel / 🇺🇸 Richard Ciamarra

• 🇺🇸 Catherine Harrison / 🇺🇸 Robert Galloway

• 🇺🇸 Madison Keys / 🇺🇸 Bjorn Fratangelo

• 🇺🇸 Caty McNally / 🇺🇸 William Blumberg

• 🇺🇸 Robin Montgomery / 🇺🇸 Nicholas Monroe

• 🇺🇸 Alycia Parks / 🇺🇸 Christopher Eubanks

• 🇺🇸 Bernarda Pera / 🇺🇸 Jackson Withrow

Protected ranking
• 🇧🇪 Kirsten Flipkens / 🇫🇷 Édouard Roger-Vasselin

• 🇨🇿 Lucie Hradecká / 🇵🇱 Łukasz Kubot

• 🇯🇵 Ena Shibahara / Franko Škugor

Alternates
• 🇳🇿 Erin Routliffe / 🇩🇪 Andreas Mies

Withdrawals

 * 🇫🇷 Alizé Cornet / 🇫🇷 Nicolas Mahut → replaced by 🇳🇿 Erin Routliffe / 🇩🇪 Andreas Mies