2016 US Open – Mixed doubles

Martina Hingis and Leander Paes were the defending champions, but lost in the second round to CoCo Vandeweghe and Rajeev Ram.

Laura Siegemund and Mate Pavić won the title, defeating Vandeweghe and Ram in the final, 6–4, 6–4.

Seeds
• # 🇮🇳 Sania Mirza / Ivan Dodig (second round)

• # 🇰🇿 Yaroslava Shvedova / 🇧🇷 Bruno Soares (quarterfinals)

• # 🇺🇸 Bethanie Mattek-Sands / 🇷🇴 Horia Tecău (withdrew)

• # 🇺🇸 Raquel Atawo / Jean-Julien Rojer (first round)

• # Chan Hao-ching / 🇧🇾 Max Mirnyi (second round)

• # 🇨🇿 Andrea Hlaváčková / 🇵🇱 Łukasz Kubot (second round)

• # 🇺🇸 CoCo Vandeweghe / 🇺🇸 Rajeev Ram (final)

• # 🇨🇿 Lucie Hradecká / 🇵🇱 Marcin Matkowski (first round)

Wild cards
• 🇺🇸 Emina Bektas / 🇺🇸 Evan King

• 🇺🇸 Nicole Gibbs / 🇺🇸 Dennis Novikov

• Martina Hingis / 🇮🇳 Leander Paes

• 🇺🇸 Jamie Loeb / 🇺🇸 Noah Rubin

• 🇺🇸 Christina McHale / 🇺🇸 Ryan Harrison

• 🇺🇸 Melanie Oudin / 🇺🇸 Mitchell Krueger

• 🇺🇸 Taylor Townsend / 🇺🇸 Donald Young

• 🇺🇸 Sachia Vickery / 🇺🇸 Frances Tiafoe

Alternates
• Jeļena Ostapenko / 🇦🇹 Oliver Marach

• 🇺🇦 Olga Savchuk / 🇸🇪 Robert Lindstedt