2003 US Open – Mixed doubles

Lisa Raymond and Mike Bryan were the defending champions, but lost in the quarterfinals to Cara Black and Wayne Black.

Katarina Srebotnik and Bob Bryan won the title, defeating Lina Krasnoroutskaya and Daniel Nestor in the final 5–7, 7–5, [10–5].

Seeds
• # 🇦🇷 Paola Suárez / 🇮🇳 Mahesh Bhupathi (second round, withdrew)

• # 🇺🇸 Lisa Raymond / 🇺🇸 Mike Bryan (quarterfinals)

• # 🇪🇸 Virginia Ruano Pascual / Mark Knowles (quarterfinals)

• # 🇷🇺 Elena Likhovtseva / 🇦🇺 Todd Woodbridge (second round)

• # 🇷🇺 Lina Krasnoroutskaya / 🇨🇦 Daniel Nestor (final)

• # 🇸🇰 Janette Husárová / 🇨🇿 Leoš Friedl (semifinal)

• # Cara Black /  Wayne Black (semifinal)

• # Katarina Srebotnik / 🇺🇸 Bob Bryan (champions)