2019 US Open – Mixed doubles

Bethanie Mattek-Sands and Jamie Murray were the defending champions and successfully defended their title, defeating Chan Hao-ching and Michael Venus in the final, 6–2, 6–3. This is the third straight Mixed Doubles title Murray has won at the US Open, following his championships in 2018 (with Mattek-Sands) and 2017 (with Martina Hingis).

Seeds
• # Chan Hao-ching / 🇳🇿 Michael Venus (final)

• # 🇨🇦 Gabriela Dabrowski / Mate Pavić (quarterfinals)

• # 🇦🇺 Samantha Stosur / 🇺🇸 Rajeev Ram (semifinals)

• # Latisha Chan /  Ivan Dodig (semifinals)

• # 🇺🇸 Nicole Melichar / 🇧🇷 Bruno Soares (second round)

• # Demi Schuurs / 🇫🇮 Henri Kontinen (quarterfinals)

• # 🇩🇪 Anna-Lena Grönefeld / 🇦🇹 Oliver Marach (first round)

• # 🇨🇿 Květa Peschke / Wesley Koolhof (quarterfinals)