2010 US Open – Mixed doubles

Carly Gullickson and Travis Parrott were the defending champions, but lost in the first round to Gisela Dulko and Pablo Cuevas.

Liezel Huber and Bob Bryan won the title, defeating Květa Peschke and Aisam-ul-Haq Qureshi in the final 6–4, 6–4.

Seeds
• # 🇺🇸 Liezel Huber / 🇺🇸 Bob Bryan (champions)

• # Cara Black / 🇮🇳 Leander Paes (quarterfinals)

• # 🇸🇮 Katarina Srebotnik / 🇷🇸 Nenad Zimonjić (second round)

• # 🇺🇸 Bethanie Mattek-Sands / 🇨🇦 Daniel Nestor (semifinals)

• # 🇦🇺 Rennae Stubbs / 🇧🇪 Dick Norman (first round)

• # 🇷🇺 Elena Vesnina / 🇮🇱 Andy Ram (second round)

• # 🇺🇸 Lisa Raymond / Wesley Moodie (quarterfinals)

• # 🇺🇸 Vania King / 🇷🇴 Horia Tecău (first round)