1980 US Open – Mixed doubles

Greer Stevens and Bob Hewitt were the defending champions but lost in the quarterfinals to Candy Reynolds and Steve Denton.

Wendy Turnbull and Marty Riessen won in the final 7–5, 6–2 against Betty Stöve and Frew McMillan.

Seeds
Champion seeds are indicated in bold text while text in italics indicates the round in which those seeds were eliminated.

• # 🇦🇺 Wendy Turnbull / 🇺🇸 Marty Riessen (champions)

• # Betty Stöve / Frew McMillan (final)

• # 🇺🇸 Anne Smith / Kevin Curren (semifinals)

• # Greer Stevens /  Bob Hewitt (quarterfinals)

• # 🇺🇸 Rosemary Casals / 🇮🇳 Anand Amritraj (first round)

• # 🇺🇸 Candy Reynolds / 🇺🇸 Steve Denton (semifinals)

• # 🇺🇸 Ann Kiyomura / 🇺🇸 Tom Leonard (quarterfinals)

• # 🇺🇸 Betsy Nagelsen / Francisco González (first round)