1999 US Open – Women's singles

Serena Williams defeated Martina Hingis in the final, 6–3, 7–6(7–4) to win the women's singles tennis title at the 1999 US Open. It was her first major singles title, the first of an eventual Open Era joint-record six US Open titles, and the first of an eventual Open Era record 23 major singles titles. Williams became the first African American woman in the Open Era to win a singles major.

Lindsay Davenport was the defending champion, but lost to Williams in the semifinals.

Seeds
• # Martina Hingis (final)

• # 🇺🇸 Lindsay Davenport (semifinals)

• # 🇺🇸 Venus Williams (semifinals)

• # 🇺🇸 Monica Seles (quarterfinals)

• # 🇫🇷 Mary Pierce (quarterfinals)

• # Amanda Coetzer (first round)

• # 🇺🇸 Serena Williams (champion)

• # 🇨🇿 Jana Novotná (third round)

• # 🇫🇷 Julie Halard-Decugis (fourth round)

• # 🇪🇸 Arantxa Sánchez Vicario (fourth round)

• # 🇫🇷 Nathalie Tauziat (third round)

• # 🇦🇹 Barbara Schett (quarterfinals)

• # 🇧🇪 Dominique Van Roost (third round)

• # 🇫🇷 Sandrine Testud (second round)

• # 🇫🇷 Amélie Mauresmo (fourth round)

• # 🇪🇸 Conchita Martínez (fourth round)