2008 Mutua Madrileña Masters Madrid – Singles

Andy Murray defeated Gilles Simon in the final, 6–4, 7–6(8–6) to win the singles tennis title at the 2008 Madrid Open. It was his second Masters title.

David Nalbandian was the defending champion, but lost in the third round to Juan Martín del Potro.

This was the last edition of the tournament to be held on indoor hard courts, as it would switch to outdoor clay courts the following year.

Seeds
All seeds receive a bye into the second round. • # 🇪🇸 Rafael Nadal (semifinals)

• # Roger Federer (semifinals)

• # 🇷🇸 Novak Djokovic (third round)

• # 🇬🇧 Andy Murray (champion)

• # 🇷🇺 Nikolay Davydenko (second round)

• # 🇪🇸 David Ferrer (second round)

• # 🇦🇷 David Nalbandian (third round)

• # 🇺🇸 Andy Roddick (third round)

• # 🇦🇷 Juan Martín del Potro (quarterfinals)

• # Stanislas Wawrinka (third round)

• # 🇺🇸 James Blake (second round)

• # Fernando González (second round)

• # 🇪🇸 Fernando Verdasco (second round)

• # Ivo Karlović (quarterfinals)

• # 🇫🇷 Richard Gasquet (third round)

• # 🇫🇷 Jo-Wilfried Tsonga (third round)

Qualifying seeds
• # 🇷🇸 Janko Tipsarević (first round)

• # 🇮🇹 Simone Bolelli (qualifying competition, Lucky loser)

• # 🇦🇷 José Acasuso (qualifying competition)

• # Ivan Ljubičić (qualifying competition)

• # 🇦🇷 Agustín Calleri (first round)

• # 🇫🇷 Julien Benneteau (qualifying competition)

• # 🇫🇷 Florent Serra (qualified)

• # 🇦🇷 Eduardo Schwank (qualifying competition)

• # 🇪🇸 Marcel Granollers (qualified)

• # 🇧🇪 Steve Darcis (qualified)

• # 🇪🇸 Guillermo García López (first round)

• # 🇦🇷 Guillermo Cañas (qualifying competition)

Qualifiers
• # 🇺🇸 Robby Ginepri

• # 🇧🇪 Steve Darcis

• # 🇫🇷 Florent Serra

• # 🇪🇸 Marcel Granollers

• # 🇧🇪 Olivier Rochus

• # Victor Hănescu

Lucky loser

 * 1) 🇮🇹 Simone Bolelli