2008 Australian Open – Men's singles

Novak Djokovic defeated Jo-Wilfried Tsonga in the final, 4–6, 6–4, 6–3, 7–6(7–2) to win the men's singles tennis title at the 2008 Australian Open. It was his first major title, the first of a record ten Australian Open titles, and the first of an all-time record 24 major men's singles titles overall. Djokovic became the first Serbian man to win a major singles title. It was the first major final since the 2005 Australian Open not to feature either Roger Federer or Rafael Nadal, who were beaten by Djokovic and Tsonga, respectively, in the semifinals. Alongside second-seeded Nadal, Tsonga (unseeded in this tournament) defeated three more seeds en route to the final, including ninth-seed Andy Murray.

Federer was the two-time defending champion, but lost to Djokovic in the semifinals. The loss ended Federer's record streak of 10 consecutive major finals. However, he became the first man to reach 15 consecutive major quarterfinals (streak starting at the 2004 Wimbledon Championships), surpassing Roy Emerson and Ivan Lendl. This was the only major where Federer failed to reach the final between the 2005 Wimbledon Championships and the 2010 Australian Open, a span of 19 tournaments. He would go on to reach the next eight major finals (winning four of them).

Seeds
• Roger Federer (semifinals)

• 🇪🇸 Rafael Nadal (semifinals)

• 🇷🇸 Novak Djokovic (champion)

• 🇷🇺 Nikolay Davydenko (fourth round)

• 🇪🇸 David Ferrer (quarterfinals)

• 🇺🇸 Andy Roddick (third round)

• Fernando González (third round)

• 🇫🇷 Richard Gasquet (fourth round)

• 🇬🇧 Andy Murray (first round)

• 🇦🇷 David Nalbandian (third round)

• 🇪🇸 Tommy Robredo (second round)

• 🇺🇸 James Blake (quarterfinals)

• 🇨🇿 Tomáš Berdych (fourth round)

• 🇷🇺 Mikhail Youzhny (quarterfinals)

• 🇨🇾 Marcos Baghdatis (third round)

• 🇪🇸 Carlos Moyá (first round)

•  Ivan Ljubičić (first round)

• 🇦🇷 Juan Ignacio Chela (first round)

• 🇦🇺 Lleyton Hewitt (fourth round)

•  Ivo Karlović  (third round)

• 🇦🇷 Juan Mónaco  (third round)

• 🇪🇸 Juan Carlos Ferrero (fourth round)

• 🇫🇷 Paul-Henri Mathieu (fourth round)

• 🇫🇮 Jarkko Nieminen (quarterfinals)

• 🇪🇸 Fernando Verdasco (second round)

•  Stanislas Wawrinka (second round)

• 🇪🇸 Nicolás Almagro (first round)

• 🇫🇷 Gilles Simon (third round)

• 🇩🇪 Philipp Kohlschreiber (fourth round)

• 🇨🇿 Radek Štěpánek (first round)

• 🇷🇺 Igor Andreev (third round)

• 🇷🇺 Dmitry Tursunov (second round)