2012 Abierto Mexicano Telcel – Women's singles

Sara Errani defeated Flavia Pennetta in the final, 5–7, 7–6(7–2), 6–0 to win the women's singles tennis title at the 2012 Mexican Open.

Gisela Dulko was the reigning champion, but withdrew due to gastrointestinal illness.

Seeds
• # 🇮🇹 Roberta Vinci (semifinals)

• # 🇮🇹 Flavia Pennetta (final)

• # 🇮🇹 Sara Errani (champion)

• # 🇷🇴 Irina-Camelia Begu (semifinals)

• # 🇷🇴 Alexandra Dulgheru (first round)

• # 🇸🇪 Johanna Larsson (second round)

• # 🇦🇷 Gisela Dulko (withdrew due to gastro-intestinal illness)

• # 🇮🇹 Alberta Brianti (second round)

Seeds
• # 🇷🇴 Edina Gallovits-Hall (qualified)

• # 🇪🇸 Lara Arruabarrena-Vecino (first round)

• # 🇦🇷 Paula Ormaechea (first round)

• # 🇫🇷 Aravane Rezaï (first round)

• # 🇰🇿 Sesil Karatantcheva (qualified)

• # 🇷🇺 Anastasia Pivovarova (first round)

• # 🇷🇴 Mihaela Buzărnescu (first round)

• # 🇺🇸 Julia Cohen (first round)

Qualifiers
• # 🇷🇴 Edina Gallovits-Hall

• # Petra Rampre

• # 🇨🇴 Mariana Duque-Mariño

• # 🇰🇿 Sesil Karatantcheva

Lucky losers

 * 1) 🇪🇸 Estrella Cabeza Candela