2012 Kremlin Cup – Women's singles

Dominika Cibulková was the defending champion, but she was defeated in the quarterfinals by Caroline Wozniacki.

Wozniacki went on to win the title, defeating Samantha Stosur in the final 6–2, 4–6, 7–5.

Seeds
The top four seeds received a bye into the second round.

• # 🇦🇺 Samantha Stosur (final)

• # 🇫🇷 Marion Bartoli (second round)

• # Caroline Wozniacki (champion)

• # 🇷🇸 Ana Ivanovic (semifinals)

• # 🇸🇰 Dominika Cibulková (quarterfinals)

• # 🇷🇺 Nadia Petrova (first round)

• # 🇷🇺 Maria Kirilenko (quarterfinals)

• # 🇨🇿 Lucie Šafářová (second round)

Seeds
• # 🇰🇿 Sesil Karatantcheva (first round)

• # 🇷🇺 Olga Puchkova (qualifying competition, retired)

• # 🇺🇦 Lesia Tsurenko (first round)

• # 🇸🇰 Jana Čepelová (second round)

• # 🇪🇸 María-Teresa Torró-Flor (qualifying competition)

• # 🇨🇿 Kristýna Plíšková (qualifying competition)

• # 🇨🇿 Karolína Plíšková (second round)

• # 🇦🇺 Anastasia Rodionova (qualified)

Qualifiers
• # 🇷🇺 Valeria Solovieva

• # 🇦🇺 Anastasia Rodionova

• # 🇷🇸 Vesna Dolonc

• # 🇺🇦 Elina Svitolina