2012 Copa Sony Ericsson Colsanitas – Singles

Lourdes Domínguez Lino was the defending champion, but lost in the second round to Mariana Duque-Mariño. Lara Arruabarrena Vecino won the title, defeating Alexandra Panova in the final with the score of 6–2, 7–5. All seeded players lost in the first or second round.

Seeds
• # 🇳🇿 Marina Erakovic (second round)

• # 🇷🇴 Alexandra Dulgheru (first round)

• # Romina Oprandi (second round)

• # 🇦🇺 Jelena Dokić (first round)

• # 🇦🇷 Gisela Dulko (second round)

• # 🇫🇷 Mathilde Johansson (first round)

• # 🇪🇸 Lourdes Domínguez Lino (second round)

• # 🇦🇹 Patricia Mayr-Achleitner (first round)

Seeds
• # 🇦🇷 Paula Ormaechea (qualified)

• # 🇰🇿 Sesil Karatantcheva (qualified)

• # Monica Puig (second round)

• # 🇰🇿 Yaroslava Shvedova (qualified)

• # 🇪🇸 Leticia Costas-Moreira (qualifying competition)

• # 🇮🇹 Corinna Dentoni (qualifying competition)

• # 🇪🇸 Inés Ferrer Suárez (qualified)

• # 🇸🇮 Nastja Kolar (first round)

Qualifiers
• # 🇦🇷 Paula Ormaechea

• # 🇰🇿 Sesil Karatantcheva

• # 🇪🇸 Inés Ferrer Suárez

• # 🇰🇿 Yaroslava Shvedova