2012 Estoril Open – Women's singles

Anabel Medina Garrigues was the defending champion, but lost in the second round to Sílvia Soler Espinosa.

Kaia Kanepi won the tournament, defeating in the final Carla Suárez Navarro 3–6, 7–6(8–6), 6–4.

Seeds
• # 🇮🇹 Roberta Vinci (semifinals)

• # 🇷🇺 Maria Kirilenko (second round)

• # 🇪🇸 Anabel Medina Garrigues (second round)

• # 🇨🇿 Petra Cetkovská (quarterfinals)

• # 🇨🇳 Zheng Jie (second round)

• # 🇪🇪 Kaia Kanepi (champion)

• # 🇷🇺 Nadia Petrova (quarterfinals)

• # 🇩🇪 Mona Barthel (withdrew because of a left foot injury)

• # Polona Hercog (second round, retired)

Seeds
• # 🇺🇸 Sloane Stephens (qualifying competition, lucky loser)

• # 🇫🇷 Stéphanie Foretz Gacon (second round)

• # 🇦🇺 Anastasia Rodionova (second round)

• # Arantxa Rus (first round)

• # 🇬🇧 Heather Watson (qualified)

• # 🇨🇿 Andrea Hlaváčková (first round)

• # 🇰🇿 Sesil Karatantcheva (second round)

• # 🇪🇸 Lara Arruabarrena Vecino (qualifying competition)

Qualifiers
• # 🇬🇧 Heather Watson

• # 🇮🇹 Karin Knapp

• # 🇪🇸 María-Teresa Torró-Flor

• # 🇩🇪 Kristina Barrois

Lucky loser

 * 1) 🇺🇸 Sloane Stephens