2012 Brisbane International – Women's singles

Petra Kvitová was the defending champion, but she decided to play at the Hopman Cup instead.

Kaia Kanepi won the title, defeating Daniela Hantuchová in the final 6–2, 6–1.

Seeds
• # 🇦🇺 Samantha Stosur (second round)

• # 🇩🇪 Andrea Petkovic (quarterfinals)

• # 🇮🇹 Francesca Schiavone (semifinals)

• # 🇺🇸 Serena Williams (quarterfinals, withdrew due to left ankle sprain)

• # 🇧🇪 Kim Clijsters (semifinals, retired due to left hip flexor injury)

• # 🇷🇸 Jelena Janković (quarterfinals)

• # 🇷🇺 Anastasia Pavlyuchenkova (second round)

• # 🇸🇰 Dominika Cibulková (first round)

Seeds
• # 🇺🇸 Vania King (qualified)

• # Arantxa Rus (first round)

• # 🇷🇺 Vera Dushevina (qualified)

• # Anna Tatishvili (qualifying competition)

• # Eleni Daniilidou (second round)

• # Michaëlla Krajicek (first round)

• # 🇺🇸 Sloane Stephens (first round)

• # 🇦🇹 Patricia Mayr-Achleitner (first round)

Qualifiers
• # 🇺🇸 Vania King

• # 🇷🇺 Nina Bratchikova

• # 🇷🇺 Vera Dushevina

• # 🇷🇺 Alexandra Panova