2006 Internationaux de Strasbourg – Singles

Anabel Medina Garrigues was the defending champion, but was defeated in the semifinals by Peng Shuai. Nicole Vaidišová won the title, defeating Peng in the final 7–6(9–7), 6–3.

Seeds
• # Patty Schnyder (second round)

• #🇨🇿 Nicole Vaidišová (champion)

• #🇫🇷 Nathalie Dechy (second round)

• #🇪🇸 Anabel Medina Garrigues (semifinals)

• #🇫🇷 Marion Bartoli (second round)

• #🇦🇷 Gisela Dulko (first round)

• #🇨🇳 Zheng Jie (quarterfinals)

• # Jelena Janković (semifinals)