2021 Sardegna Open – Singles

Lorenzo Sonego defeated defending champion Laslo Đere in the final, 2–6, 7–6(7–5), 6–4 to win the men's singles title at the 2021 Sardegna Open. With the victory, Sonego became the first Italian in 15 years to capture an ATP Tour title on home soil.

Seeds
The top four seeds received a bye into the second round. • # 🇬🇧 Dan Evans (second round)

• # 🇺🇸 Taylor Fritz (semifinals)

• # 🇮🇹 Lorenzo Sonego (champion)

• # Nikoloz Basilashvili (semifinals)

• # 🇩🇪 Jan-Lennard Struff (quarterfinals)

• # 🇦🇺 John Millman (second round)

• # 🇦🇷 Guido Pella (first round)

• # 🇺🇸 Tommy Paul (first round)

Seeds
• # 🇸🇰 Jozef Kovalík (qualified)

• # 🇩🇪 Cedrik-Marcel Stebe (qualifying competition, retired)

• # 🇮🇳 Sumit Nagal (qualified)

• # 🇦🇹 Jurij Rodionov (qualifying competition)

• # 🇺🇸 Brandon Nakashima (first round)

• # Marc-Andrea Hüsler (qualified)

• # 🇺🇸 Maxime Cressy (first round)

• # 🇬🇧 Liam Broady (qualified)

Qualifiers
• # 🇸🇰 Jozef Kovalík

• # Marc-Andrea Hüsler

• # 🇮🇳 Sumit Nagal

• # 🇬🇧 Liam Broady