2021 Wimbledon Championships – Mixed doubles

Neal Skupski and Desirae Krawczyk defeated Joe Salisbury and Harriet Dart in the final, 6–2, 7–6(7–1), to win the mixed doubles tennis title at the 2021 Wimbledon Championships. It was Krawczyk's second consecutive major title in mixed doubles, following her success at the French Open.

Ivan Dodig and Latisha Chan were the defending champions from when the tournament was last held in 2019, but lost in the third round to John Peers and Zhang Shuai.

Seeds
All seeds received a bye into the second round. • 🇫🇷 Nicolas Mahut / 🇫🇷 Kristina Mladenovic (withdrew)

• Mate Pavić / 🇨🇦 Gabriela Dabrowski (quarterfinals)

•  Wesley Koolhof /  Demi Schuurs (second round)

• 🇫🇷 Édouard Roger-Vasselin / 🇺🇸 Nicole Melichar (quarterfinals)

• 🇺🇸 Rajeev Ram / 🇺🇸 Bethanie Mattek-Sands (third round, withdrew)

•  Ivan Dodig /  Latisha Chan (third round)

• 🇬🇧 Neal Skupski / 🇺🇸 Desirae Krawczyk (champions)

• 🇳🇿 Michael Venus /  Chan Hao-ching (withdrew)

• 🇩🇪 Kevin Krawietz / 🇨🇿 Květa Peschke (semifinals)

•  Raven Klaasen /  Darija Jurak (third round)

•  Hugo Nys /  Hsieh Su-wei (withdrew)

• 🇫🇷 Fabrice Martin /  Alexa Guarachi (second round)

• 🇧🇪 Sander Gillé / 🇺🇸 Hayley Carter (third round)

•  Jean-Julien Rojer /  Andreja Klepač (quarterfinals)

• 🇯🇵 Ben McLachlan / 🇯🇵 Ena Shibahara (withdrew)

• 🇳🇿 Marcus Daniell / 🇨🇦 Sharon Fichman (withdrew)

• 🇦🇺 John Peers / 🇨🇳 Zhang Shuai (semifinals)

Wild cards
• 🇫🇷 Jérémy Chardy / 🇬🇧 Naomi Broady

• 🇬🇧 Lloyd Glasspool / 🇬🇧 Jodie Burrage

• 🇦🇺 Nick Kyrgios / 🇺🇸 Venus Williams

• 🇬🇧 Jonny O'Mara / 🇬🇧 Sarah Beth Grey

• 🇬🇧 Ryan Peniston / 🇬🇧 Eden Silva

Protected ranking
• Ariel Behar / 🇰🇿 Galina Voskoboeva

• 🇮🇳 Rohan Bopanna / 🇮🇳 Sania Mirza

• 🇪🇨 Gonzalo Escobar / 🇷🇺 Vera Zvonareva

• 🇪🇸 Marc López / 🇨🇿 Marie Bouzková

Alternates
• 🇩🇪 Andre Begemann / 🇩🇪 Vivian Heisen

• 🇬🇧 Arthur Fery / 🇬🇧  Tara Moore

• 🇬🇧 Aidan McHugh / 🇬🇧 Emily Webley-Smith

•  David Pel /  Rosalie van der Hoek

• 🇮🇳 Ramkumar Ramanathan / 🇮🇳 Ankita Raina

• 🇮🇳 Divij Sharan / 🇬🇧 Samantha Murray Sharan

Withdrawals
• 🇰🇿 Alexander Bublik / 🇷🇺 Anastasia Pavlyuchenkova
 * During the tournament

• 🇳🇿 Marcus Daniell / 🇨🇦 Sharon Fichman

• 🇬🇧 Lloyd Glasspool / 🇬🇧 Jodie Burrage

• 🇦🇺 Nick Kyrgios / 🇺🇸 Venus Williams

• 🇯🇵 Ben McLachlan / 🇯🇵 Ena Shibahara

• 🇦🇺 Max Purcell / 🇺🇦 Marta Kostyuk

• 🇺🇸 Rajeev Ram / 🇺🇸 Bethanie Mattek-Sands

• 🇳🇿 Michael Venus / Chan Hao-ching