2021 French Open – Mixed doubles

Desirae Krawczyk and Joe Salisbury defeated Elena Vesnina and Aslan Karatsev in the final, 2–6, 6–4, [10–5] to win the mixed doubles title at the 2021 French Open. It was Krawczyk's first major title, and was Salisbury's first major title in mixed doubles. Additionally, this was Vesnina's first major final since returning from pregnancy, and Karatsev's first major final in any discipline. Vesnina and Karatsev were the first Russian team to reach the French Open mixed doubles final.

Latisha Chan and Ivan Dodig were the two-time defending champions, but lost in the first round to Demi Schuurs and Wesley Koolhof.

This was the first edition of this event since 2019, as the 2020 edition was cancelled due to the COVID-19 pandemic. The tournament featured only 16 teams, instead of the usual 32 teams.

Seeds
• # 🇨🇿 Barbora Krejčíková / 🇸🇰 Filip Polášek (quarterfinals)

• # 🇺🇸 Nicole Melichar / 🇺🇸 Rajeev Ram (quarterfinals)

• # Demi Schuurs / Wesley Koolhof (semifinals)

• # 🇨🇳 Xu Yifan / 🇧🇷 Bruno Soares (first round)

Wild cards
• 🇫🇷 Alizé Cornet / 🇫🇷 Édouard Roger-Vasselin

• 🇫🇷 Caroline Garcia / 🇫🇷 Nicolas Mahut

Protected ranking
• 🇷🇺 Elena Vesnina / 🇷🇺 Aslan Karatsev

Alternate pair
• 🇩🇪 Laura Siegemund / 🇧🇪 Sander Gillé

Withdrawals

 * Before the tournament
 * 🇨🇦 Gabriela Dabrowski / Mate Pavić → replaced by 🇨🇦 Gabriela Dabrowski / 🇦🇺 Luke Saville
 * 🇺🇸 CoCo Vandeweghe / 🇦🇹 Jürgen Melzer → replaced by 🇩🇪 Laura Siegemund / 🇧🇪 Sander Gillé