2006 Australian Open – Men's singles

Roger Federer defeated Marcos Baghdatis in the final, 5–7, 7–5, 6–0, 6–2 to win the men's singles tennis title at the 2006 Australian Open. It was his second Australian Open title and his seventh major title overall. Baghdatis became the first Cypriot to reach a major final.

Marat Safin was the defending champion, but withdrew due to injury.

Seeds
• # Roger Federer (champion)

• # 🇺🇸 Andy Roddick (fourth round)

• # 🇦🇺 Lleyton Hewitt (second round)

• # 🇦🇷 David Nalbandian (semifinals)

• # 🇷🇺 Nikolay Davydenko (quarterfinals)

• # 🇦🇷 Guillermo Coria (third round)

• # Ivan Ljubičić (quarterfinals)

• # 🇦🇷 Gastón Gaudio (third round)

• # Fernando González (first round)

• # 🇸🇪 Thomas Johansson (fourth round)

• # 🇪🇸 David Ferrer (fourth round)

• # 🇸🇰 Dominik Hrbatý (fourth round)

• # 🇺🇸 Robby Ginepri (second round)

• # 🇫🇷 Richard Gasquet (first round)

• # 🇪🇸 Juan Carlos Ferrero (third round)

• # 🇪🇸 Tommy Robredo (fourth round)

• # 🇨🇿 Radek Štěpánek (second round)

• # Mario Ančić (third round)

• # 🇨🇿 Tomáš Berdych (second round)

• # 🇺🇸 James Blake (third round)

• # 🇩🇪 Nicolas Kiefer (semifinals)

• # 🇫🇷 Gaël Monfils (first round)

• # 🇷🇺 Igor Andreev (third round)

• # 🇧🇪 Olivier Rochus (second round)

• # 🇫🇷 Sébastien Grosjean (quarterfinals)

• # 🇫🇮 Jarkko Nieminen (third round)

• # 🇺🇸 Taylor Dent (first round)

• # 🇪🇸 Fernando Verdasco (second round)

• # 🇮🇹 Filippo Volandri (first round, retired)

• # 🇧🇾 Max Mirnyi (third round)

• # 🇪🇸 Feliciano López (third round)

• # 🇪🇸 Carlos Moyá (first round)