2021 Open 13 Provence – Singles

Daniil Medvedev defeated Pierre-Hugues Herbert in the final, 6–4, 6–7(4–7), 6–4 to capture the men's singles tennis title at the 2021 Open 13 Provence.

Stefanos Tsitsipas was the two-time defending champion, but lost in the quarterfinals to Herbert.

Medvedev overtook Rafael Nadal as the number 2 ranking following the tournament. This marked the first time in over 15 years that someone outside of the Big Four has been ranked number 2, the last person being Lleyton Hewitt on July 18, 2005.

Seeds
The top four seeds received a bye into the second round. • #🇷🇺 Daniil Medvedev (champion)

• # Stefanos Tsitsipas (quarterfinals)

• #🇷🇺 Karen Khachanov (quarterfinals)

• #🇫🇷 Ugo Humbert (semifinals)

• #🇮🇹 Jannik Sinner (quarterfinals)

• #🇯🇵 Kei Nishikori (first round)

• #🇪🇸 Alejandro Davidovich Fokina (second round)

• #🇯🇵 Yoshihito Nishioka (first round, retired)

Seeds
• # 🇫🇷 Antoine Hoang (first round)

• # 🇦🇺 Marc Polmans (first round)

• # 🇫🇷 Arthur Rinderknech (qualified)

• # 🇪🇸 Bernabé Zapata Miralles (first round)

• # 🇺🇸 Maxime Cressy (qualifying competition)

• # 🇸🇰 Filip Horanský (first round)

• # 🇨🇦 Steven Diez (qualifying competition, retired)

• # Frederico Ferreira Silva (first round)

Qualifiers
• # 🇸🇰 Alex Molčan

• # 🇫🇷 Constant Lestienne

• # 🇫🇷 Arthur Rinderknech

• # 🇦🇺 Matthew Ebden