2016 BB&T Atlanta Open – Singles

John Isner was the three-time defending champion, but lost in the final to Nick Kyrgios, 6–7(3–7), 6–7(4–7). Kyrgios was the first non-American winner in the tournament's history.

Seeds
The top four seeds receive a bye into the second round. • #🇺🇸 John Isner (final)

• #🇦🇺 Nick Kyrgios (champion)

• # Kevin Anderson (second round)

• #🇺🇦 Alexandr Dolgopolov (second round)

• #🇪🇸 Fernando Verdasco (quarterfinals)

• #🇪🇸 Guillermo García López (first round)

• #🇺🇸 Donald Young (quarterfinals)

• #🇺🇸 Taylor Fritz (quarterfinals)

Seeds
• # 🇧🇷 Thiago Monteiro (qualifying competition, lucky loser)

• # 🇩🇪 Tobias Kamke (qualifying competition, lucky loser)

• # 🇺🇸 Austin Krajicek (qualified)

• # 🇩🇪 Mischa Zverev (qualified)

• # 🇦🇺 James Duckworth (qualifying competition)

• # 🇺🇸 Tommy Paul (first round)

• # 🇦🇺 John-Patrick Smith (qualified)

• # 🇺🇸 Alexander Sarkissian (first round)

Qualifiers
• # 🇺🇸 Christopher Eubanks

• # 🇦🇺 John-Patrick Smith

• # 🇺🇸 Austin Krajicek

• # 🇩🇪 Mischa Zverev

Lucky losers
• # 🇧🇷 Thiago Monteiro

• # 🇩🇪 Tobias Kamke