2016 Western & Southern Open – Men's doubles

Daniel Nestor and Édouard Roger-Vasselin were the defending champions, but chose not to compete together. Nestor played alongside Vasek Pospisil, but lost in the semifinals to Ivan Dodig and Marcelo Melo. Roger-Vasselin teamed up with Julien Benneteau, but lost in the first round to Milos Raonic and Nenad Zimonjić.

Dodig and Melo won the title, defeating Jean-Julien Rojer and Horia Tecău in the final, 7–6(7–5), 6–7(5–7), [10–6].

Seeds
All seeds received a bye into the second round. • # 🇫🇷 Pierre-Hugues Herbert / 🇫🇷 Nicolas Mahut (quarterfinals)

• # 🇺🇸 Bob Bryan / 🇺🇸 Mike Bryan (semifinals)

• # 🇬🇧 Jamie Murray / 🇧🇷 Bruno Soares (quarterfinals)

• # Ivan Dodig / 🇧🇷 Marcelo Melo (champions)

• # Jean-Julien Rojer / 🇷🇴 Horia Tecău (final)

• # 🇨🇦 Daniel Nestor / 🇨🇦 Vasek Pospisil (semifinals)

• # 🇮🇳 Rohan Bopanna / 🇷🇴 Florin Mergea (second round)

• # Raven Klaasen / 🇺🇸 Rajeev Ram (quarterfinals)