2022 Citi Open – Men's singles

Nick Kyrgios defeated Yoshihito Nishioka in the final, 6–4, 6–3 to win the men's singles tennis title at the 2022 Washington Open. It was his second Washington title, following 2019. Kyrgios saved five match points en route to the title, in the quarterfinals against Frances Tiafoe. He also did not drop serve during the tournament.

Jannik Sinner was the reigning champion, but did not compete.

Seeds
All seeds received a bye into the second round. • Andrey Rublev (semifinals)

• 🇵🇱 Hubert Hurkacz (second round)

• 🇺🇸 Taylor Fritz (third round, retired)

• 🇺🇸 Reilly Opelka (third round)

• 🇧🇬 Grigor Dimitrov (third round)

• 🇨🇦 Denis Shapovalov (second round)

• Karen Khachanov (third round)

• Botic van de Zandschulp (third round)

• Holger Rune (third round)

• 🇺🇸 Frances Tiafoe (quarterfinals)

• 🇦🇺 Alex de Minaur (second round)

• 🇦🇷 Sebastián Báez (second round)

• 🇺🇸 Maxime Cressy (third round)

• 🇺🇸 Tommy Paul (second round)

• Aslan Karatsev (second round)

• 🇬🇧 Dan Evans (quarterfinals)

Seeds
• # 🇯🇵 Taro Daniel (qualified)

• # 🇩🇪 Dominik Koepfer (qualified)

• # 🇺🇸 Michael Mmoh (qualified)

• # 🇺🇸 Mitchell Krueger (qualifying competition)

• # 🇫🇷 Antoine Escoffier (qualifying competition)

• # Wu Tung-lin (qualified)

• # 🇺🇸 Bjorn Fratangelo (first round)

• # Borna Gojo (qualified)

• # 🇯🇵 Yosuke Watanuki (qualified)

• # 🇺🇸 Alex Rybakov (qualifying competition)

• # 🇯🇵 Shintaro Mochizuki (qualifying competition)

• # 🇺🇸 JC Aragone (qualifying competition)

Qualifiers
• # 🇯🇵 Taro Daniel

• # 🇩🇪 Dominik Koepfer

• # 🇺🇸 Michael Mmoh

• # 🇯🇵 Yosuke Watanuki

• # Borna Gojo

• # Wu Tung-lin