2010 Barcelona Ladies Open – Singles

Roberta Vinci was the defending champion, but lost in the final to Francesca Schiavone, 6–1, 6–1.

Seeds
• # 🇮🇹 Francesca Schiavone (champion)

• # 🇫🇷 Aravane Rezaï (first round)

• # 🇪🇸 María José Martínez Sánchez (second round)

• # 🇷🇺 Maria Kirilenko (second round)

• # 🇷🇴 Sorana Cîrstea (second round)

• # 🇦🇷 Gisela Dulko (first round)

• # 🇪🇸 Carla Suárez Navarro (quarterfinals)

• # 🇨🇿 Lucie Šafářová (first round)