2010 Australian Open – Mixed doubles

Sania Mirza and Mahesh Bhupathi were the defending champions, but withdrew before their first round match against Carly Gullickson and Bernard Tomic. They were replaced in the draw by Akgul Amanmuradova and Rik de Voest.

Cara Black and Leander Paes won the mixed doubles title at the 2010 Australian Open, defeating Ekaterina Makarova and Jaroslav Levinský in the final 7–5, 6–3.

Seeds
• # Cara Black / 🇮🇳 Leander Paes (champions)

• # 🇸🇰 Daniela Hantuchová / 🇨🇦 Daniel Nestor (second round, withdrew)

• # 🇺🇸 Bethanie Mattek-Sands / 🇺🇸 Bob Bryan (second round)

• # 🇪🇸 Nuria Llagostera Vives / 🇸🇰 Michal Mertiňák (first round)

• # 🇷🇺 Maria Kirilenko / 🇷🇸 Nenad Zimonjić (first round)

• # 🇷🇺 Alisa Kleybanova / 🇧🇾 Max Mirnyi (second round)

• # 🇺🇸 Lisa Raymond / Wesley Moodie (semifinals)

• # 🇷🇺 Elena Vesnina / 🇮🇱 Andy Ram (quarterfinals)