2010 Internazionali Femminili di Palermo – Singles

Flavia Pennetta was the defending champion but lost to Kaia Kanepi in the final 6–4, 6–3.

Seeds
• # 🇮🇹 Flavia Pennetta (final)

• # 🇫🇷 Aravane Rezaï (quarterfinals)

• # 🇮🇹 Sara Errani (quarterfinals)

• # 🇧🇬 Tsvetana Pironkova (second round)

• # 🇪🇪 Kaia Kanepi (champion)

• # 🇨🇳 Peng Shuai (withdrew due to left ankle injury)

• # 🇪🇸 Arantxa Parra Santonja (first round)

• # 🇩🇪 Julia Görges (semifinals)

• # 🇮🇹 Alberta Brianti (second round)