2010 Internationaux de Strasbourg – Singles

Aravane Rezaï was the defending champion, but she chose not to participate this year.

Top-seeded Maria Sharapova won in the final 7–5, 6–1 against Kristina Barrois.

Seeds
• # 🇷🇺 Maria Sharapova (champion)

• # 🇷🇺 Elena Vesnina (first round)

• # 🇫🇷 Virginie Razzano (second round)

• # 🇨🇳 Peng Shuai (withdrew due to dizziness)

• # 🇪🇸 Anabel Medina Garrigues (semifinals)

• # 🇦🇹 Sybille Bammer (second round)

• # Anastasija Sevastova (quarterfinals)

• # 🇬🇧 Elena Baltacha (second round, retired due to back injury)