2010 Western & Southern Financial Group Masters – Doubles

Daniel Nestor and Nenad Zimonjić were the defending champions, but they lost to František Čermák and Michal Mertiňák 7–5, 6–2 in the first round. Bob Bryan and Mike Bryan won in the final against Mahesh Bhupathi and Max Mirnyi, 6–3, 6–4.

Seeds
• # 🇨🇦 Daniel Nestor / 🇷🇸 Nenad Zimonjić (second round)

• # 🇺🇸 Bob Bryan / 🇺🇸 Mike Bryan (champions)

• # 🇨🇿 Lukáš Dlouhý / 🇮🇳 Leander Paes (second round)

• # 🇮🇳 Mahesh Bhupathi / 🇧🇾 Max Mirnyi (final)

• # 🇵🇱 Łukasz Kubot / 🇦🇹 Oliver Marach (semifinals)

• # 🇦🇹 Julian Knowle / 🇮🇱 Andy Ram (quarterfinals)

• # 🇦🇹 Jürgen Melzer / 🇩🇪 Philipp Petzschner (second round)

• # 🇵🇱 Mariusz Fyrstenberg / 🇵🇱 Marcin Matkowski (quarterfinals)