2010 Australian Open – Men's doubles

Bob and Mike Bryan were the defending champions, and successfully defended their title after winning 6–3, 6–7(5–7), 6–3, against Daniel Nestor and Nenad Zimonjić.

Seeds
• # 🇺🇸 Bob Bryan / 🇺🇸 Mike Bryan (champions)

• # 🇨🇦 Daniel Nestor / 🇷🇸 Nenad Zimonjić (final)

• # 🇨🇿 Lukáš Dlouhý / 🇮🇳 Leander Paes (quarterfinals)

• # 🇮🇳 Mahesh Bhupathi / 🇧🇾 Max Mirnyi (first round)

• # 🇵🇱 Łukasz Kubot / 🇦🇹 Oliver Marach (third round)

• # 🇨🇿 František Čermák / 🇸🇰 Michal Mertiňák (first round)

• # 🇵🇱 Mariusz Fyrstenberg / 🇵🇱 Marcin Matkowski (second round)

• # 🇪🇸 Marcel Granollers / 🇪🇸 Tommy Robredo (second round)

• # 🇩🇪 Christopher Kas / 🇧🇪 Dick Norman (first round)

• # 🇦🇹 Julian Knowle / 🇸🇪 Robert Lindstedt (first round)

• # 🇸🇪 Simon Aspelin / 🇦🇺 Paul Hanley (third round)

• # 🇧🇷 Marcelo Melo / 🇧🇷 Bruno Soares (first round)

• # 🇫🇷 Michaël Llodra / 🇮🇱 Andy Ram (first round)

• # 🇨🇿 Martin Damm / 🇸🇰 Filip Polášek (second round)

• # 🇨🇿 Jaroslav Levinský / 🇺🇸 Travis Parrott (first round)

• # 🇺🇸 James Blake / 🇺🇸 Mardy Fish (withdrew)

• # 🇦🇹 Jürgen Melzer / 🇩🇪 Philipp Petzschner (third round)