2010 Pilot Pen Tennis – Men's singles

Fernando Verdasco was the defending champion, but chose not to compete in 2010. Sergiy Stakhovsky won in the final against Denis Istomin, 3–6, 6–3, 6–4.

Seeds
All seeds received a bye into the second round. • # 🇨🇾 Marcos Baghdatis (quarterfinals)

• # 🇧🇷 Thomaz Bellucci (second round)

• # Fernando González (second round)

• # 🇺🇸 Mardy Fish (withdrew due to fatigue)

• # 🇰🇿 Andrey Golubev (third round)

• # 🇪🇸 Tommy Robredo (third round)

• # 🇺🇦 Alexandr Dolgopolov (third round)

• # 🇩🇪 Florian Mayer (third round)

• # 🇺🇦 Sergiy Stakhovsky (champion)

• # 🇷🇸 Viktor Troicki (semifinals)

• # 🇧🇪 Xavier Malisse (second round, retired)

• # Thiemo de Bakker (semifinals)

• # 🇩🇪 Michael Berrer (second round)

• # 🇦🇷 Juan Ignacio Chela (third round)

• # 🇺🇿 Denis Istomin (final)

• # 🇷🇴 Victor Hănescu (third round)