2010 Mutua Madrileña Madrid Open – Men's doubles

Daniel Nestor and Nenad Zimonjić were the defending champions, but they lost in the final against Bob and Mike Bryan 3–6, 4–6.

Seeds
All seeds receive a bye into the second round. • # 🇨🇦 Daniel Nestor / 🇷🇸 Nenad Zimonjić (final)

• # 🇺🇸 Bob Bryan / 🇺🇸 Mike Bryan (champions)

• # 🇨🇿 Lukáš Dlouhý / 🇮🇳 Leander Paes (semifinals)

• # Wesley Moodie  / 🇧🇪 Dick Norman (second round)

• # 🇸🇪 Simon Aspelin / 🇦🇺 Paul Hanley (second round)

• # 🇵🇱 Łukasz Kubot / 🇦🇹 Oliver Marach (quarterfinals)

• # 🇨🇿 František Čermák / 🇸🇰 Michal Mertiňák (second round)

• # 🇵🇱 Mariusz Fyrstenberg / 🇵🇱 Marcin Matkowski (quarterfinals)