2010 Italian Open – Men's doubles

Daniel Nestor and Nenad Zimonjić were the defending champions, but lost in the second round to Pablo Cuevas and Juan Mónaco.

Bob Bryan and Mike Bryan defeated their compatriots John Isner and Sam Querrey in the final. They won 6–2, 6–3.

Seeds
All seeds receive a bye into the second round. • # 🇨🇦 Daniel Nestor / 🇷🇸 Nenad Zimonjić (second round)

• # 🇺🇸 Bob Bryan / 🇺🇸 Mike Bryan (champions)

• # 🇨🇿 Lukáš Dlouhý / 🇮🇳 Leander Paes (quarterfinals)

• # 🇮🇳 Mahesh Bhupathi / 🇧🇾 Max Mirnyi (second round)

• # Wesley Moodie / 🇧🇪 Dick Norman (second round)

• # 🇸🇪 Simon Aspelin / 🇦🇺 Paul Hanley (second round)

• # 🇵🇱 Łukasz Kubot / 🇦🇹 Oliver Marach (semifinals)

• # Mark Knowles / 🇧🇷 Bruno Soares (second round)